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KMID : 0624620150480020081
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BMB Reports
2015 Volume.48 No. 2 p.81 ~ p.90
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Structure and apoptotic function of p73
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Yoon Mi-Kyung
Ha Ji-Hyang
Lee Min-Sung
Chi Seung-Wook
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Abstract
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p73 is a structural and functional homologue of the p53 tumor suppressor protein. Like p53, p73 induces apoptosis and cell cycle arrest and transactivates p53-responsive genes, conferring its tumor suppressive activity. In addition, p73 has unique roles in neuronal development and differentiation. The importance of p73-induced apoptosis lies in its capability to substitute the pro-apoptotic activity of p53 in various human cancer cells in which p53 is mutated or inactive. Despite the great importance of p73-induced apoptosis in cancer therapy, little is known about the molecular basis of p73-induced apoptosis. In this review, we discuss the p73 structures reported to date, detailed structural comparisons between p73 and p53, and current understanding of the transcription-dependent and -independent mechanisms of p73-induced apoptosis.
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KEYWORD
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Apoptosis, Cancer therapy, p53 protein family, p73, Structure
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